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Standard rules for this. Thankfully Wimbledon has only recently given up the middle Sunday, so the idea that they'll start on a Sunday must be decades away.
1. Pick quarterfinalists, semifinalists and champions for both ATP and WTA draws. You will receive 7.5 points for each correct quarterfinalist, 5 points for each correct semifinalist and 20 points for each correct champion.
2. SUBSTITUTE PICK: Pick a player from each draw to replace one of your quarterfinalists. If this player makes the quarters, they will take the place of whomever you picked in that section of the draw.
3. BIGGEST LOSER: pick the highest seed that will lose in the earliest round from each draw. The player must be a top-16 seed. You get 5 points if your seed is the highest to lost and 2 points if your seed falls in the same round as the highest seed to lose.
Picks must be posted by the time play begins or soon afterwards.
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Women
Quarterfinals
Sabalenka v Keys
Paolini v Ostapenko
Krejcikova v Pegula
Rybakina v Kenin (Gauff)
Semifinals
Keys v Ostapenko
Krejicikova v Rybakina
Final
Keys d. Rybakina
BL: Zheng
Men
Quarterfinals
Sinner v Shelton
Draper (Bublik) v De Minaur
Fritz v Zverev
Tiafoe v Alcaraz
Semifinals
Shelton v Draper
Fritz v Alcaraz
Final
Alcaraz d Draper
BL: Medvedev
I am not going to be tricked into doing my usual pick of Zverev over Fritz only to be reminded again and again that Fritz has Zverev's number. Maybe if these players stopped returning fifteen feet behind the baseline, they'd do better.
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MEN
Quarterfinals
Sinner over Musetti
Djokovic over Bublik (Draper)
Fritz over Zverev
Alcaraz over Lehecka
Semifinals
Sinner over Djokovic
Alcaraz over Fritz
Final
Alcaraz over Sinner 7-6, 3-6, 6-4, 7-5
Biggest loser: Rune
WOMEN
Quarterfinals
Keys over Vondrousova
Zheng over Anisimov
Pegula (Alexandrova) over Andreeva
Rybakina over Samsonova
Semifinals
Keys over Zheng
Rybakina over Pegula
Final
Rybakina over Keys 7-6, 6-3
Biggest loser: Gauff
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We hit on all four of our biggest losers. I get the full five points for Gauff and two points for Rune. You get two points for Zheng and two points for Medvedev. What a wild first round.